![]() Keywordsīhalala OG, Srikanth M, Kessler JA (2013) The emerging roles of microRNAs in CNS injuries. Finally, the challenges and future potentialities have been addressed. Further, we have discussed the recent advances of electrospun polymeric scaffolds in neural tissue engineering. ![]() In this book chapter, we have demonstrated the principal parameters necessary for suitable electrospinning. These produced fibers can be random or oriented to assist the extension of neurite via contact guidance. The electrospun substrates have a high prospective in mimicking the structure of the natural extracellular matrix. Majorly, the electrospinning method has come into the limelight for the fabrication of the scaffolds as they can develop fibrous meshes with fiber diameter in nanoscale dimensions. Lately, tissue engineering methods have enticed many scientists to lead tissue regeneration efficiently. Therefore, a successful therapeutic approach to bring functional rehabilitation is immediately required. The continuing functional loss owing to inadequate regeneration of the nerve is a significant problem around the world. Though the peripheral nerves regenerate to some extent, the consequent findings are not satisfactory, especially for severe injuries. ![]() Furthermore, the existing therapeutic modalities comprising the utilization of conventional grafts and pharmacological actives have numerous shortcomings and cannot completely rehabilitate injuries to the nervous system. The complication of the structure and function of the nervous system, and its slow rate of regeneration, make it further challenging to treat in comparison to other human tissues when damage takes place. The repairing procedure in the nervous system is intricate and brings significant difficulties to investigators.
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